The immune system is supposed to be our greatest defense in defending against pathogens and rebuilding damaged tissue. Without it, your cold would win and your sore back would never heal. Chronic inflammation, brought on by an immune system in overdrive, could lead to illnesses including cancer, heart disease and diabetes.
Inflammation-signaling cells or C-reactive proteins (CRP), is a molecule released by the liver as part of the immune response. These levels should go back to normal levels after defending the body, but instead hang out in the blood. What keeps the battle going? Recurring irritants, such as cigarette smoke, for one. Or, as we now know, carrying too much extra weight, or simply getting older.
The efficiency with which your liver detoxes your blood and circulation are two huge contributing factors to your CRP levels.
“It’s very subtle,” says Professor Joel Mason, director of the Vitamins and Carcinogenesis Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts. “It’s inflammation on a biochemical level.”
During a full-blown infection, for example, you might see your CRP level shoot up from 0mg/L (of blood) to 1,000mg/L. Chronic inflammation, on the other hand, might register a benign-looking 3 mg/L. But even at such a slow burn, this silent war takes a toll on the body. A CRP level of 3mg/L is enough to triple your risk of heart disease. In fact, chronic inflammation is connected to many of the illnesses we see more often as we age.
“It’s very subtle,” says Professor Joel Mason, director of the Vitamins and Carcinogenesis Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts. “It’s inflammation on a biochemical level.”
“Inflammation is thought to be an important basis not just for cancer, but for insulin resistance and diabetes and atherosclerotic disease and any number of other conditions,” Mason says. “There is a lot of research going on into what role inflammation plays in a lot of the chronic degenerative diseases that our society falls prey to.”
Inflammation and Obesity
And guess what inflammation is connected to? Enlarged fat cells bring on inflammation for a number of reasons. They release fatty acids into the blood, which seem to spur an inflammatory response. People who carry a lot of weight also tend to have high numbers of macrophages in their fat. Macrophages are immune system weapons that normally gobble up pathogens or dead cells.
Researchers believe the body sends the macrophages to clean up dead fat cells, the numbers of which increase dramatically with obesity. Once there, the macrophages infiltrate the fat and start sending out pro-inflammatory signals. In laboratory studies, obese mice that had excess macrophages started making a lot more insulin, and eventually developed insulin resistance.
“With obesity, there is a release of fatty acids and other factors that fuel inflammation and insulin resistance,” says Atkins Professor in Metabolism and Nutrition Andrew Greenberg, director of the HNRCA’s Obesity and Metabolism Laboratory.
For a long time, scientists thought that the extra fat we carry on our bodies was fairly inert stuff—just more baggage to slow us down. But more recent studies, including groundbreaking research by Greenberg, have shown that fat is actually a hormonal powerhouse. As people gain weight, their fat cells grow larger.
When that happens, the cells churn out several inflammation-inducing proteins, known as cytokines. And they do it at a surprising rate. One of these cytokines is Interleukin-6. You usually find IL-6 when the body’s immune system is doing its day job, fighting an infection or trying to heal a burn, for example.
So what can you do?
- Take a test. It is called a C-reactive Themesprotein test, and it measures the degree of HIDDEN inflammation in your body.

- Change your diet. Eating anti-inflammatory foods (berries, fish, leafy greens, almonds) can provide your cardiovascular system with the efficiency it needs to cleanse the blood of these cytokines that keep the inflammation levels present.
- Take a supplement. I recommend Now Foods Liver Detoxifier and Regenerator. I like vegetarian gel caps because they are made of plant cell walls, so they break down easier in your stomach allowing for a more efficient absorption. They also contain Tumeric and Milk Thistle Extract, which has been shown in clinical and non-clinical studies to support the liver, as measured by standard liver enzyme laboratory tests. In addition, it contains N-Acetyl Cysteine and Methionine, two amino acids known to enhance the production of glutathione in the liver. Glutathione, a major cellular antioxidant, plays an essential role in liver detoxification mechanisms. Also included in this Liver Formula are other herbs (Schisandra, Bupleurum, and Scute) that have been shown in non-clinical studies to support healthy liver function.


































